Global Scans · chromosonal · Weekly Summary

• In multiple studies presented at 2025's EHA Annual Congress, the third-generation tyrosine kinase inhibitor olverembatinib showed broad therapeutic potential and demonstrated particular clinical benefit in the treatment of Philadelphia chromosome-positive acute lymphoblastic leucaemia. ASCENTAGE PHARMA GROUP INTERNATIONAL
• Increasing Indigenous American chromosomal copy at 6 q25 reduced Bca risk, while increasing European chromosomal copy increased Bca risk. PubMed Central (PMC)
• The virtual population consisted of 100000 singleton pregnant women, who have similar characteristics to Quebec's pregnant women aged 14-49 years in terms of age distribution and risk for a fetal chromosomal anomaly. BMJ Open
• The dominant indirect effect of low LET irradiation is mainly induced through water radiolysis products, which can cause DNA breaks and complex chromosomal aberrations, protein denaturation, cell membrane disruption, enzyme inactivation, and DNA or RNA mutations. Nickel
• With expanded NIPT, healthcare providers can obtain a comprehensive view of all 23 chromosome pairs while limiting risk to their patient. / Thailand Illumina
• AB8939 intellectual property rights in AML are secured until 2036 through a 'composition of matter' patent and potentially until 2044 in AML with chromosome abnormality, including MECOM, through a 'second medical use' patent. MarketScreener
• Researchers in 2017 showed that using CRISPR allows CAR gene insertion at a precise location in the chromosome, which makes the CAR-T cells more potent: Therefore, improved therapy options and clinical trials for fighting cancer using this method are likely to surface in the near future. Synbiology
• E. faecalis are capable of producing hydroxyl radical, which causes genetic mutations, DNA breaks, and chromosomal instability, increasing the risk of CRC. BioMed Central
• National federations will be responsible for testing and will be required to confirm the sex of their athletes when entering them into World Boxing competitions by producing certification of their chromosomal sex, as determined by a PCR test. Al Jazeera
• Currently, the most commonly applied approach for AML risk stratification is the European LeukemiaNet (ELN), which stratifies patients into different risk groups according to cytogenetic and chromosomal abnormalities. BioMed Central

Last updated: 14 September 2025